По неизвестной причине умирает все мужское население Земли. В живых остаются только молодой американец Йорик и его ручная обезьянка. Последний мужчина планеты отправляется в опасное путешествие через непростой мир женщин на поиски своей возлюбленной. По дороге он наблюдает шокирующие перемены, произошедшие с человечеством после катастрофы.

Volume 4 - 1st printing. "Safeword!" Collects Y the Last Man #18-23. Written by Brian K. Vaughan Art by Pia Guerra, Goran Parlov & José Marzán, Jr. Cover by Massimo Carnevale. The fourth collection of the acclaimed Vertigo series, Y: THE LAST MAN ? SAFEWORD reprints issues #18-23 of writer Brian K. Vaughan's and artist Pia Guerra's dynamic series. As the Last Man on Earth and his companions continue to head West, the story takes a detour into the psychological. In the care of a fellow Culper Ring member, Yorick Brown is forced to confront his tremendous feelings of survivor guilt that lead him to constantly put his life in danger. Once on the road again, the group runs up against a literal roadblock in Arizona, where the female remains of the Sons of Arizona militia have cut the interstate to keep out any vestiges of the U.S. government. Softcover, 144 pages, full color  MATURE AUDIENCES